Our team at Columbia (Prof. Qiao Lin, Principal Investigator; Profs. Milan Stojanovic and Tilla Worgall, Co-Investigators) has recently received an award from the National Cancer Institute (NCI) of the National Institutes of Health (NIH) to validate microfluidic technology for rapid discovery of aptamers as personalized reagents for precision medicine. We will initially investigate the development and utility of such reagents in personalized diagnostics in multiple myeloma care, and then expand to the diagnosis and therapy of other disorders.
February 2017: Exploring commercialization of microfluidic aptamer selection for personalized monitoring of minimal residual disease in multiple myeloma
We are starting to explore commercialization of aptamers in personalized cancer diagnostics with funding from a Columbia-Coulter Translational Research Partnership award to Profs. Qiao Lin and Tilla Worgall (Columbia Medical Center). In this effort, we will develop personalized aptameric assays for serum-based monitoring of minimal residual disease in multiple myeloma, a blood cancer.
July 2016: Jaeyoung Yang's Paper Featured in Analytical Methods
The paper "Integrated microfluidic aptasensor for mass spectrometric detection of vasopressin in human plasma ultrafiltrater" was featured as a cover article in Analytical Methods. Authored by Dr. Jaeyoung Yang, Dr. Jing Zhu, Prof. Renjun Pei, J. A. Oliver, D. W. Landry, Prof. Milan Stojanovic, and Prof. Qiao Lin, the paper presents a microfluidic aptamer-based biosensor for detection of low-molecular-weight biomarkers in patient samples.
January 2016: Papers at MEMS 2016
Ph.D. student Xuejun Wang presented his paper at the 29th IEEE International Conference on Micro Electro Mechanical Systems (MEMS 2016), Shanghai, China. The paper was entitled “An Aptameric Graphene Nanosensor for Analyte Detection in Serum”.
November 2015: Huawei Best Sensor Award at IEEE-NanoMed 2015
The paper “MEMS-Based Differential Calorimetry for Biomolecular Characterization” received the Huawei Best Sensor Paper award at the 9th IEEE International Conference on Nano/Molecular Medicine and Engineering (IEEE-NanoMed 2015), Waikiki Beach, Hawaii. The authors for the paper included Professor Qiao Lin and Ph.D. students Yuan Jia, Bin Wang, and Xiangsong Feng.
November 2015: Presentations at MicroTAS 2015
Ph.D. students Yuan Jia and Xiangsong Feng, Tim Olsen, and Zhixing Zhang and Junyi Shang presented their papers at the 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2015), Gyeongju, Korea. The papers were entitled “A Polymeric MEMS Device using 3D Diffusive Titration for Isothermal Titration Calorimetry” (Jia), “Microfluidic Isolation of Aptamers Using Free Solution Electrophoretic Control” (Olsen) and “A MEMS Dielectric Affinity Glucose Sensor Using Hydrogel-functionalized Coplanar Electrodes” (Zhang and Shang).
August 2015: New Grant on Microfluidic Selection of Glycan-Targeting Reagents
Together with Professor Milan Stojanovic at the Columbia Medical Center, Professor Lin has received a grant from the National Institutes of Health (NIH) to develop and validate microfluidic technology for isolation of aptamers toward glycomics applications. The technology will allow aptamers (synthetic, short single-stranded DNA with affinity to other molecules) to be produced, in a rapid and automated fashion, to target glycans (compounds consisting of a large number of glycosidically linked monosaccharides) or their substructures.
July 2015: New Grant on Contact Lens-Based Glucose Nanosensors
Professor Qiao Lin has received a grant from the National Science Foundation (NSF) to develop a contact lens-based affinity nanosensor, which will use polymer-functionalized graphene to enable continuous monitoring of glucose in tears in the eye. The device will be constructed by an interdisciplinary approach combining graphene nanotechnology, synthetic polymer chemistry, and flexible micro-electro-mechanical systems. This research will be conducted in collaboration with Professor Qian Wang, Department of Chemistry and Biochemistry, University of South Carolina, and Professor James Hone, Department of Mechanical Engineeirng, Columbia University.
July 2015: Tim Receives Precision Medicine Fellowship
Tim Olsen has been appointed as a precision medicine trainee from the Irving Institute for Clinical and Translational Research, Columbia University. The program provides research funding and additional interdisciplinary training to help prepare for an academic research career. Tim's research focuses on leveraging microfluidic technology to rapidly isolate new affinity biomolecules that can be used for personalized diagnostic and therapeutic strategies in precision medicine.
June 2015: Presentations at Transducers 2015
Ph.D. students Ryan Jia, Junyi Shang and Zhixing Zhang, and Yibo Zhu presented their papers at the 18th International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers 2015), Anchorage, Alaska. The papers were entitled “A Heat Induced Bi-layer Lift-off Method for Flexible Substrates” (Jia), “A Hydrogel-based MEMS Dielectric Affinity Glucose Sensor” (Shang and Zhang) and “A Graphene-based Affinity Glucose Nanosensor” (Zhu).
April 2015: New Grant in Precision Medicine
We are excited to start a new project in Precision Medicine through funding from Columbia's Irving Institute for Clinical and Translational Research to Professors Tilla Worgall and Milan Stojanovic (Columbia Medical Center) and Qiao Lin. Precision Medicine seeks to improve disease treatment and prevention by accounting for variabilities in environment, lifestyle, and genes of individuals. In this project, we seek to develop microfluidic technology capable of producing aptamers (synthetic, short single-stranded DNA that recognize disease biomarkers) as reagents in personalized monitoring of a patient treated for multiple myeloma (a common blood cancer).
January 2015: Presentations at MEMS 2015 Conference
Dr. Jaeyoung Yang, and Ph.D. students Tim Olsen and Yibo Zhu presented their papers at the 28th IEEE International Conference on Micro Electro Mechanical Systems (MEMS 2015), Estoril, Portugal. The papers were entitled “A Microfluidic Aptasensor Integrating Specific Enrichment with A Graphene Nanosensor for Label-free Detection of Small Biomolecules” (Yang), “A Microfluidic SELEX Device Using Combined Electrokinetic and Hydrodynamic Manipulation” (Olsen) and “A Solid-gated Graphene FET Sensor for pH Measurements” (Zhu).
December 2014: Jaeyoung Yang Receives Ph.D. Degree
Jaeyoung Yang successfully defended his Ph.D. dissertation entitled “Micro and Nanoscale Aptasensors for Detection of Low-Molecular-Weight Biomarkers towards Clinical Diagnostic Applications.” Congratulations, Dr. Yang!
February 2014: Jaeyoung Yang's Work Selected as Keynote Presentation at Biosensors 2014
The work, "A magnetic nanopaticle-clustering biosensor for blu-ray based optical detection of small-molecules," will be a keynote presentation at the 24th World Congress on Biosensors 2014 (Biosensors 2014), Melbourne, Australia, May 27-30, 2014. Selected as one of 12 keynote presentations from about 1,200 submitted abstarts, this work is authored by J. Yang, M. Donolato, P. Antunes, A. Pinto, F. Giacomo Bosco, E. Hwu, C Chen, P. Vavassori, A. Boisen, M. Hansen and Q. Lin, this collaborative work between DTU, CIC nanoGUNE, Academia Sinica and Columbia presents a Blu-ray based optical biosensor for ATP via inhibitive assembly of oligonucleotide-conjugated magnetic nanoparticles.
January 2014: Xiang Huang's Paper Featured in Lab on a Chip
The paper "A differential dielectric affinity glucose sensor" was featured as a cover article in Lab on a Chip. Authored by Dr. Xiang Huang, Dr. Charles Leduc, Dr. Yann Ravussin, Dr. Siqi Li, Erin Davis, Bing Song, Prof. Dachao Li, Prof. Kexin Xu, Dr. Domenico Accili and Prof. Qiao Lin, the paper presents an implantable micro-electro-mechanical affinity sensor for continuous glucose monitoring in diabetes care.
December 2013: Jing Zhu Defends his Thesis
April 2013: Jing Zhu's Paper Awarded Inaugural C.M. Ho Best Paper in Micro/Nano Fluidics at NEMS 2013
The paper "Physical Modulation Based Cell Manipulation on a Microchip" won the inaugural C.M. Ho Best Paper in Micro/Nano Fluidics award at the IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS 2013), Suzhou, China, April 7-10, 2013. The paper was selected for the award among five Finalists from over 300 papers presented at the conference by researchers from over the world. Authored by Jing Zhu, Junyi Shang, Yuan Jia, Prof. Kun Liu, Prof. David Brenner, and Prof. Qiao Lin, the paper reports on innovative approaches that exploit modulation of physical stimuli, such as temperature and mechanical force, to isolate, trap and retrieve cells
September 2013: Jinho Kim Defends his Thesis
January 2013: Jinho Kim's Paper Selected Outstanding Poster Finalist at MEMS 2013
The paper "Electrokinetically Integrated Microfluidic Isolation and Amplification of Biomolecule- and Cell- Binding Nucleic Acids" was selected as a finalist for the Outstanding Poster Paper award at the IEEE International Conference on Micro Electro Mechanical Systems (MEMS 2013), Taipei, Taiwan, January 20-24, 2013. The paper was one of 10 Outstanding Poster Paper Finalists, which were chosen from 311 papers presented at the conference. The authors of the paper are Jinho Kim, John P. Hilton, Dr. Kyung-Ae Yang, Prof. Renjun Pei, Jing Zhu, Prof. Milan Stojanovic, and Prof. Qiao Lin. The paper presents a microfluidic device for a rapid enrichment of target-binding nucleic acids to a wide range of targets including small molecules, proteins, and cells with high binding affinity.