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MEMS-based Characterization of Temperature-Dependent Biomolecular Interactions


Biomolecular interactions and conformational transitions in general evolve heat and are temperature dependent. A detailed understanding of such thermally active behavior can provide valuable insight into the biomolecular systems. Unfortunately, conventional techniques for such biophysical measurements, while requiring large amounts of biological material, are tedious, labor intensive, and time consuming. MEMS technology ideally offers integrated and miniaturized platforms that maximally mitigate or even eliminate these limitations. Along these lines, we have been developing MEMS devices that integrate thermal transducers with microfluidics for measurement of temperature-dependent biomolecular reactions and conformational transitions.