Thermally controlled characterization of biomolecules
Most biomolecular interactions and conformational transitions are thermally active in that they evolve heat and/or are temperature dependent. Thus, MEMS-based measurement of heat can yield valuable insights into biomolecular systems. Additionally, MEMS bioanalytical devices with integrated temperature control allow innovative exploitation and study of thermally dependent processes inherent to many biomolecular systems. Along these lines, we are currently developing devices that integrate thermal sensing and control elements with microfluidics for measurement of biomolecular reactions.
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